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What is the Difference between In-Vivo Research Methodologies and In-Vitro Research?

We all know there are many words. When we speak about scientific terms, they are especially complex and new to us. Today, we will discuss two scientific terms in detail.

You may have heard the words “in vivo” or “in vitro” while researching scientific investigations. You may have heard of them while discussing in-vitro fertilization.

These terms have you ever come across? We’ll let you know what they mean. Let’s start by asking what these terms actually mean in real life.

Continue reading to learn more about these concepts and see examples from real-world situations. We also discuss their benefits and disadvantages.

InVivo and InVitro: What Does It Mean?

Do you know the basic definitions of In-Vivo or In-Vitro research methods? Let’s take a closer look at their meanings.


Latin’s invivo is “among the living.” This refers to the experiments, methods, and tests that scientists perform in or on complete live species such as a person, a laboratory animal, or a flora.


In-vitro, a Latin term that means “in glass”, is the Latin term. This term refers to diagnostic procedures, scientific testing, or research that is performed by researchers without the presence of a living thing. An in-vitro experiment takes place in a sterile setting, like a test tube or petri dish.

Difference between In-vivo and In-vitro Research Methodologies

We now know what these terms mean. Let’s talk about the differences between them.

In-vivo Research

Unfavorable side effect results are the reason that approximately 28% fail human clinical trials for medicine hypotheses. The expected outcome is not possible with an additional 55%.

In-vivo pharmacology testing is an essential part of medical research, especially clinical trials. In-vivo studies in living organisms (in vivo) provide valuable information about the effects of a substance or the development a disease.

Animal Studies

Researchers use animal studies to determine the causes of various diseases and evaluate the safety of new medical treatments.

Clinical Testing

If in vitro or animal testing show that a drug candidate is safe and effective, researchers will perform clinical testing.

In-vitro Research

In-vitro Pharmacology testing is done in a laboratory setting. This involves the analysis of cultivated microbes, animal cells, and human blood. Researchers can now examine a variety of biological processes in one cell using this technology without worrying about confounding factors in whole animals.

In-vitro testing is a simple research tool. In-vitro testing is simpler than animal or human trials. Biological researchers can conduct more detailed analyses and assess the biological impacts of larger numbers of in-vitro subjects. Because they cannot accurately predict how a living organism would react, in-vitro data should be carefully interpreted.

Pharmacological testing

New medications, also known as drug candidates, are first tested in vitro before they go into medical testing. In-vitro testing is required to determine if a new medicine has any carcinogenic or harmful effects.

Fertility treatments

In-vitro fertilization refers to a type of fertility therapy in which fertilization occurs outside the body in a laboratory. IVF involves the removal of one or more eggs from an ovary and placing them in a petri dish containing donor sperm.

The Bottom Line

Overall, both In-vivo pharmacology and In-vitro methods are important for their respective purposes. You can contact a company that provides biology research services if you need in-vivo pharmaceutical services.

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